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Nonlinear Dynamics
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ATCC
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ATCC
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Image Search Results
Journal: Antiviral Chemistry & Chemotherapy
Article Title: Frequent cross-resistance to rilpivirine among subtype C HIV-1 from first-line antiretroviral therapy failures in South Africa
doi: 10.1177/2040206618762985
Figure Lengend Snippet: Rilpivirine Cross-Resistance of HIV-1 from 100 Individuals Failing First-Line Antiretroviral Therapy. The adjusted IC 90 was calculated by multiplying the IC 50 by 2 to approximate IC 90 values and applying a rilpivirine (RPV) human serum binding factor (18.5) as determined in rilpivirine susceptibility experiments comparing human serum and fetal bovine serum (data not shown). RPV FC values were determined by dividing the IC 90 generated for each plasma-derived virus by a composite IC 90 from 12 treatment-naive plasma-derived viruses collected form the same geographical region. The dashed line indicates the RPV phenotypic biological cutoff of 2.5 FC. The IC 90 values of samples 90 through 100 exceeded the highest concentration of RPV that could be tested in TZMbl cells without cytotoxicity and are reported as >340 ng/mL.
Article Snippet: RPV was obtained through the AIDS Research and Reference Reagent Program, Division of AIDS, NIAID,
Techniques: Binding Assay, Generated, Clinical Proteomics, Derivative Assay, Virus, Concentration Assay
Journal: Antiviral Chemistry & Chemotherapy
Article Title: Frequent cross-resistance to rilpivirine among subtype C HIV-1 from first-line antiretroviral therapy failures in South Africa
doi: 10.1177/2040206618762985
Figure Lengend Snippet: Cross-Resistance to Rilpivirine of Plasma-Derived Viruses from Individuals on Failing First-Line NNRTI-Based ART.
Article Snippet: RPV was obtained through the AIDS Research and Reference Reagent Program, Division of AIDS, NIAID,
Techniques: Clinical Proteomics
Journal: Antiviral Chemistry & Chemotherapy
Article Title: Frequent cross-resistance to rilpivirine among subtype C HIV-1 from first-line antiretroviral therapy failures in South Africa
doi: 10.1177/2040206618762985
Figure Lengend Snippet: Association of NNRTI resistance mutations with rilpivirine cross-resistance.
Article Snippet: RPV was obtained through the AIDS Research and Reference Reagent Program, Division of AIDS, NIAID,
Techniques:
Journal: Antiviral Chemistry & Chemotherapy
Article Title: Frequent cross-resistance to rilpivirine among subtype C HIV-1 from first-line antiretroviral therapy failures in South Africa
doi: 10.1177/2040206618762985
Figure Lengend Snippet: Combined effect of NNRTI resistance mutations on RPV cross-resistance. FC resistance was evaluated based on the contribution of the number of RPV-associated mutations (L100I, K101E/P, E138A/G/K/Q/R, V179L, Y181C/I/V, Y188L, H221Y, F227C and M230I/L) per sample with and without K103N. Samples are grouped based on having zero, one or two RPV-associated mutations. Samples containing three or more RPV-associated mutations could not be evaluated due to insufficient numbers. Samples with zero RPV-associated mutations include the 12 treatment-naïve individuals that were used as wild-type comparators in this study. Each group displays box-and-whisker plots of interquartile FC ranges for all samples in the category (white), samples without K103N (shaded) and samples containing K103N (diagonal stripes). The dotted red line indicates the RPV phenotypic resistance biological cutoff of 2.5 FC. RPV: rilpivirine.
Article Snippet: RPV was obtained through the AIDS Research and Reference Reagent Program, Division of AIDS, NIAID,
Techniques: Whisker Assay